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. 2019 Mar 6;9:3743. doi: 10.1038/s41598-019-40283-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Number of drugs taken with respect to the patients’ degree of disability and therapy goals. The medications were split into three groups according to the therapy goals: DMDs, symptomatic drugs and comorbidity drugs. The patients were divided into two subgroups with EDSS ≤ 3.0 (N = 143) and >3.0 (N = 163), respectively. The bars mark the average number of drugs taken and the error bars show the standard deviation. Considering the drug intake of MS patients, the numbers of symptomatic and comorbidity drugs taken were significantly higher for patients with higher degrees of disability. DMDs, disease-modifying drugs; EDSS, expanded disability status scale; MS, multiple sclerosis; N, number of patients; t, two-sample two-tailed Student’s t-test; *not assuming equal variances (Levene’s test: p < 0.05).