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. 2019 Mar 6;9:3743. doi: 10.1038/s41598-019-40283-5

Table 6.

Comparison of routes of drug administration with respect to the presence of polypharmacy.

Route of administration Polypharmacy (all medications) Polypharmacy (long-term medications only)
Pw/oP PwP Statistics Pw/oP PwP Statistics
N 133 173 177 129
buccala 0.0 (0.0) 0.0 (0.2) z = −1.762, p = 0.078U 0.0 (0.2) 0.0 (0.2) z = −1.327, p = 0.185U
conjunktivala 0.0 (0.0) 0.1 (0.3) z = −2.957, p = 0.003U 0.0 (0.1) 0.1 (0.3) z = −3.333, p = 0.001U
cutaneousa 0.0 (0.1) 0.1 (0.3) z = −2.340, p = 0.019U 0.0 (0.1) 0.1 (0.3) z = −2.712, p = 0.007U
intramusculara 0.1 (0.2) 0.0 (0.2) z = −0.757, p = 0.449U 0.1 (0.3) 0.0 (0.2) z = −0.856, p = 0.392U
intravenousa 0.4 (0.5) 0.8 (0.7) z = −5.141, p < 0.001U 0.5 (0.6) 0.8 (0.6) z = −3.868, p < 0.001U
nasala 0.0 (0.1) 0.0 (0.1) z = −0.187, p = 0.852U 0.0 (0.1) 0.0 (0.1) z = −0.225, p = 0.822U
perorala 1.7 (1.0) 6.2 (2.6) z = −14.381, p < 0.001U 2.3 (1.5) 6.9 (2.6) z = −13.596, p < 0.001U
pulmonarya 0.0 (0.1) 0.1 (0.2) z = −1.307, p = 0.191U 0.0 (0.1) 0.1 (0.3) z = −2.197, p = 0.028U
rectala 0.0 (0.0) 0.0 (0.2) z = −1.242, p = 0.214U 0.0 (0.2) 0.0 (0.1) z = −0.220, p = 0.826U
subcutaneousa 0.4 (0.6) 0.8 (0.7) z = −5.332, p < 0.001U 0.5 (0.6) 0.8 (0.7) z = −4.865, p < 0.001U
sublinguala 0.0 (0.1) 0.0 (0.2) z = −0.803, p = 0.422U 0.0 (0.1) 0.0 (0.2) z = −0.038, p = 0.970U
vaginala 0.0 (0.0) 0.0 (0.2) z = −1.762, p = 0.078U 0.0 (0.1) 0.0 (0.1) z = −0.319, p = 0.750U

N, number of patients; PwP, patients with polypharmacy; Pw/oP, patients without polypharmacy.

aMean value (standard deviation) of the number of drugs taken per patient; UMann-Whitney U test.