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. 2019 Mar 6;9:3682. doi: 10.1038/s41598-019-39998-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic risk score. Diagnostic accuracy of the Genetic risk score (GRS) for NAFLD-HCC in the 655 individuals included in the study. (a) comparison of the diagnostic accuracy in the study cohorts; p < 0.05 for diagnostic accuracy in the overall vs. single cohorts. (b) Diagnostic accuracy of GRS vs. PNPLA3 I148M variant alone and a combination of PNPLA3 I148M and TM6SF2 E167K variants in determining NAFLD HCC risk; p < 2*10⁻⁸ for alternative genetic scores vs. the overall GRS. (c) Additive value of adding GRS to a diagnostic model based on clinical risk factors, in determining NAFLD-HCC risk in the 251 individuals of the EPIDEMIC study; p = 0.17. Comparison of diagnostic accuracy was performed by two-sided Venkatraman test.