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. 2019 Mar 6;9:3750. doi: 10.1038/s41598-019-40172-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Coagulation parameters in 858K/K and 858R/R homozygotes. Distributions of the ETP^−APC (A), ETP^+APC (B) and nAPCsr (C) measured with thrombin generation-based assay, the APCsr measured with the Immonochrom assay (D), and FVIII levels (E) in 25 homozygous carriers of rs4524 (858R/R) and in 25 non-carriers (858K/K). The horizontal lines represent the means of the distributions. Please note that APC resistance increases with increasing ETP-based nAPCsr and with decreasing Immunochrom APCsr.