Table 1.
Association of F5 rs6025 and rs4524 with VT risk in four French case-control studies.
| rs6025 (R534Q) | rs4524 (K858R) | |||||||
|---|---|---|---|---|---|---|---|---|
| R/R | R/Q | Q/Q | P valuea | K/K | K/R | R/R | P valuea | |
| FVL−/FVL− | FVL+/ FVL− | FVL+/ FVL+ | ||||||
| EDITH | ||||||||
| Controls | 1103 (95%) | 56 (5%) | 1 | 8.79 10−10 | 656 (56%) | 445 (38%) | 69 (6%) | 0.0077 |
| Cases | 1030 (88%) | 138 (12%) | 3 | 704 (61%) | 396 (34%) | 51 (5%) | ||
| EOVT | ||||||||
| Controls | 1170 (95%) | 58 (5%) | 0 | 1.72 10−16 | 672 (55%) | 477 (39%) | 79 (6%) | 0.010 |
| Cases | 340 (83%) | 70 (17%) | 1 | 255 (62%) | 136 (33%) | 20 (5%) | ||
| FARIVE | ||||||||
| Controls | 561 (95%) | 27 (5%) | 0 | 8.43 10−5 | 314 (54%) | 220 (38%) | 44 (8%) | 0.0031 |
| Cases | 532 (89%) | 62 (11%) | 1 | 363 (63%) | 184 (32%) | 31 (5%) | ||
| MARTHA | ||||||||
| Controls | 1052 (95%) | 58 (5%) | 0 | 5.26 10−23 | 586 (53%) | 460 (41%) | 64 (6%) | 3.19 10−6 |
| Cases | 1202 (68%) | 340 (22%) | 0 | 973 (63%) | 490 (32%) | 79 (5%) | ||
| COMBINED | ||||||||
| Controls | 3886 (95%) | 199 (~5%) | 1 | 4.37 10−63 | 2228 (55%) | 1602 (39%) | 256 (6%) | 2.14 10−11 |
| Cases | 3104 (83%) | 610 (16%) | 5 (1‰) | 2295 (62%) | 1206 (33%) | 181 (5%) | ||
aCochran Armitage trend test’s p-value.
FVL−: absence of Factor V Leiden mutation; FVL+: presence of Factor V Leiden mutation.