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. 2019 Mar 6;9:3755. doi: 10.1038/s41598-019-40255-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Primary endpoint of conjunctival hyperemia offset time based on clinical grade. The horizontal axis represents the offset time of conjunctival hyperemia induced post-instillation of ripasudil. The vertical axis represents the number of cases within each group. The median time conjunctival hyperemia offset, as per clinical grading, was 90 min and the 95% confidence interval was 60 to 120 min post-instillation of ripasudil.