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. 2019 Mar 6;9:3755. doi: 10.1038/s41598-019-40255-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The correlation between increased clinical grade and reduced IOP. This box-whisker plot depicts the correlation between increased clinical grade and reduced IOP (mmHg). The horizontal axis indicates clinical grade (the maximum clinical grade score observed post-instillation minus baseline clinical grade score), and the vertical axis represents the reduction of IOP (the minimum of IOP post-instillation) − (the IOP of baseline). For correlations between clinical grade and IOP, there was a non-significant trend P = 0.896 (Jonckheere-Terpstra Trend Test, two-tailed test). IOP values varied widely, and outliers at the top and bottom of the box-and-whisker plot are indicated by circles.