Table 3.

Inclusion and exclusion criteria.

Inclusion criteria

• The participants were (males or females) over 20 years old with open angle glaucoma or OHT, poorly controlled by ophthalmic solutions and requiring additional treatment

• Prior treatment with one or more of prostaglandin (PG) analogs, and/or beta-blockers, and/or acetazolamide

• No history of treatment with ripasudil ophthalmic solution

Exclusion criteria

• Participants with hypersensitivity against ripasudil hydrochloride hydrate, anhydrous dihydrogen phosphate sodium, glycerin, sodium hydroxide, or concentrated benzalconium chloride liquid

• Less than −12 dB of mean deviation (MD) value

• Women of childbearing potential who were pregnant, nursing, or planning a pregnancy

• Secondary glaucoma (excluding exfoliation glaucoma)

• Angle closure glaucoma

• Refract value: Less than −9.0 D, More than +9.0 D

• Participants whose intra ocular pressure cannot be measured by the iCare Tonometer

• Participants with traumatic injuries

• Participants with ocular inflammation of the anterior segment

• Participants who cannot tolerate photo slit

• Participants having with histories of surgeries during the past 6 months.

• Users of contact lenses

• Individuals deemed unsuitable for this trial by doctors