Figure 3.

Laminin-G and EGF-like domains of EYS showing similar locations of residues labeled by foldability and disease-related mutations. The laminin-G domain (A,B) and EGF-like domain (C,D) of the EYS protein are colored by foldability (left) and the unfolding parameters of disease-causing mutations (right). The foldability scale ranges from 0 to 20, with low-foldability residues shown in blue and high-foldability residues shown in red. The tan residues on the right structure are not associated with any disease-causing mutations, while green, yellow, and red residues correspond to low-, medium-, and high-destabilization mutations. The unfolding parameter ranges from 0 to 1. Mutations colored in purple do not have an associated unfolding propensity.