Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 6;9:3676. doi: 10.1038/s41598-019-39905-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Domains represented as ribbon structures showing conserved residues (left) foldability of residues (middle), and domain secondary structure components (right). The ribbon structures in the first column highlight nonconserved residues (tan), identically conserved residues (green), and similarly conserved residues (purple). The ribbon structures in the center column are colored by a foldability gradient ranging from blue to white to red; high-foldability residues are in red, and low-foldability residues are in blue. The last column contains secondary structure component plots with motifs and disulfide bonds, as well as the domain sequence with critical residues highlighted in red. The panels show an EGF-like domain of FBN1 (A), a laminin-G domain of EYS (B), a cadherin domain of CDH23 (C), a TB domain of FBN2 (D), a sushi domain of CFH (E), and an Ig-like C2-type (F) and a fibronectin type-III domain of ROBO3 (G).