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. 2019 Mar 6;9:3676. doi: 10.1038/s41598-019-39905-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Frequency of critical residues at sequence alignment positions in groups of homologous domains. Panels show the count of critical residues which occur at all sequence alignment points of EGF-like (Panel A), laminin-G (Panel B), cadherin (Panel C), TB (Panel D), Sushi (Panel E), Ig-like C2-type (Panel F), and fibronectin type-III (Panel G) domains, respectively. The alignment consensus can be found along the x-axis, for which a corresponding key can be found in the Supplemental Fig. S7. Frequency counts of critical residues are shown in green for identically-conserved residue alignment points, and in purple for similarly-conserved residue alignment points.