Fig. 3.

Utilization and diagnostic yield of targeted NGS panels across clinical specialties: The most common specialties requesting targeted NGS testing were neurology (n = 676) and pediatrics (n = 587), accounting for 50% of all targeted NGS panels ordered at the University of Minnesota. The diagnostic yield was highest in dermatology (60%), hearing loss (49%) and ophthalmology (42%) while the diagnostic yield was lowest in gastrointestinal diseases and pulmonary diseases (10% detection yield in both specialties). The numbers within each vertical bar represent the total number of samples in each category (positive, possible or negative) within each medical specialty. Three samples were excluded as they could not be readily classified into one of the defined clinical areas.