Fig. 2.

Platelet aggregation in response to GPVI activation is increased in obese patients compared to lean matched-controls.

PRP and washed platelets were stimulated with different GPVI agonists. (A) PRP was stimulated with CRP-XL (0.1, 0.15 or 0.2 μg/mL) or Horm collagen (0.5, 0.75 or 1 μg/mL) to trigger aggregation. (B) Washed platelets were stimulated with CRP-XL (0.4, 0.5 or 1 μg/mL) and Horm collagen (1, 2 or 3 μg/mL). Results are presented as the mean ± SD; *p < 0.05, **p < 0.01, ***p < 0.001. p-values and cohort data are shown in Supplementary Table 5. OB: severe obese patients; C: lean-matched controls.