Table 1.
Histology and Specific Force of Systemically Treated mdx4cv Mice at 6 Months Post-treatment
| Group | Percentage of Dystrophin-Positive Fibers (Dys+) |
Percentage of Centrally Nucleated Fibers (CNF+) |
Percentage of Dys+ and CNF+ Fibers |
Specific Force (kN/m2) |
||||
|---|---|---|---|---|---|---|---|---|
| Gastrocnemius | Diaphragm | Gastrocnemius | Diaphragm | Gastrocnemius | Diaphragm | Gastrocnemius | Diaphragm | |
| Wild-type | 100*** | 100*** | 2 ± 1*** | 2 ± 1*** | 2 ± 1 | 2 ± 1 | 200 ± 16** | 130 ± 13* |
| μDysH3 | 64 ± 5##,*** | 85 ± 4*** | 8 ± 2*** | 3 ± 1*** | < 1 | 2 ± 1 | 201 ± 7** | 89 ± 12 |
| μDys1 | 65 ± 3##,*** | 80 ± 6*** | 12 ± 2*** | 3 ± 1*** | 2 ± 1 | < 1 | 187 ± 11 | 103 ± 7 |
| μDys2 | 31 ± 10###,** | 53 ± 9###,*** | 43 ± 5###,* | 14 ± 4##, *** | 3 ± 1 | 1 ± 1 | 210 ± 8** | 127 ± 26 |
| μDys5 | 70 ± 4#,*** | 74 ± 9*** | 14 ± 3*** | 7 ± 4*** | 1 ± 1 | 1 ± 1 | 225 ± 11*** | 148 ± 27* |
| μDys6 | 60 ± 4##,*** | 78 ± 5*** | 17 ± 4*** | 2 ± 1*** | 3 ± 1 | < 1 | 199 ± 9* | 81 ± 3 |
| μDys7 | 84 ± 5*** | 91 ± 2*** | 19 ± 3#,*** | 10 ± 1*** | 9 ± 1 | 8 ± 1 | 193 ± 8** | 99 ± 14 |
| mdx4cv | 3 ± 1### | 2 ± 1### | 58 ± 1### | 32 ± 1### | 1 ± 1 | < 1 | 132 ± 7## | 57 ± 5# |
Values represent means ± SEM. #p < 0.05, ##p < 0.01, ###p < 0.001, statistically significant difference from wild-type line. *p < 0.05, **p < 0.01, ***p < 0.001, statistically significant difference from mdx4CV. N = 4–9 per group.