Table 2.

Aerodynamic parameters of fucoidan microparticles loaded with isoniazid (INH) and rifabutin (RFB) in the combined formulation. Loaded amount of powder in the capsule was 30 mg, corresponding to 2.6 mg of INH and 1.4 mg of RFB, according to the drug content of formulation (n = 3, mean ± SD).

Drug	Metered Dose (mg)	Emitted Dose (mg)	MMAD (µm)	FPD < 5 µm (mg)	FPF < 5 µm (%)
INH	1.91 ± 0.26	1.64 ± 0.23	3.90 ± 0.01	0.82 ± 0.02	50.2 ± 2.4
RFB	1.29 ± 0.03	1.10 ± 0.02	3.64 ± 0.32	0.53 ± 0.01	45.4 ± 1.4

FPD: fine particle dose; FPF: fine particle fraction; MMAD: mass median aerodynamic diameter.