Skip to main content
. 2019 Feb 28;12:49. doi: 10.3389/fnmol.2019.00049

FIGURE 3.

FIGURE 3

Activation of VTA>NAc DA neurons increases locomotor activity. Gq rats were TH::Cre+/- rats injected in the NAc and VTA with CavFlexFlp and frt-DREADDq, respectively (n = 13); Ctl rats were either TH::Cre+/- rats injected in the NAc and VTA with CavFlexFlp and frt-mCherry, respectively, or TH::Cre-/- rats injected in the NAc and VTA with CavFlexFlp and frt-DREADDq, respectively (total n = 9); CNO administration did not increase locomotor activity in Ctl rats (Friedman test; χ2(9) = 1.556, p = 0.5690), whereas CNO significantly increased locomotor activity in Gq rats (Friedman test; χ2(13) = 0.333, p = 0.0002; Dunn’s multiple comparisons post hoc test: Saline vs. CNO 0.3 mg/kg p = 0.0004; Saline vs. CNO 1.0 mg/kg p = 0.0017); Data represented as median with interquartile range; ∗∗P < 0.01, ∗∗∗P < 0.001.