Table 5.
Kinetic modeling of IMC release from all analyzed formulations
Formulation | First order | Higuchi | Hixson-crowell | Korsmeyer-peppas | Weibull | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
R2 | k | R2 | k | R2 | k | R2 | n | k | R2 | a | b | |
PLGA-IMC | 0.846 | 0.147 | 0.916 | 47.490 | 0.783 | 0.153 | 0.957 | 0.213 | 62.452 | 0.998 | 0.983 | 0.534 |
HPON-IMC | 0.749 | 0.136 | 0.971 | 30.212 | 0.777 | 0.196 | 0.943 | 0.380 | 34.925 | 0.992 | 1.613 | 0.275 |
HPOE-IMC | 0.795 | 0.036 | 0.868 | 33.697 | 0.693 | 0.138 | 0.909 | 0.218 | 43.489 | 0.948 | 1.809 | 0.170 |
PLGA-IMC-PEG | 0.854 | 0.066 | 0.766 | 26.266 | 0.733 | 0.073 | 0.979 | 0.178 | 34.713 | 0.971 | 1.548 | 0.101 |
HPON-IMC-PEG | 0.854 | 0.129 | 0.950 | 24.690 | 0.780 | 0.169 | 0.976 | 0.259 | 30.898 | 0.994 | 1.419 | 0.170 |
HPOE-IMC-PEG | 0.931 | 0.125 | 0.911 | 11.393 | 0.880 | 0.083 | 0.981 | 0.305 | 14.216 | 0.990 | 1.172 | 0.060 |