Table 6.

Research overview: Patient stratification (1/2).

Key	Dataset(s) origin	Dataset(s) type	Dataset(s) length	Scope	Approach	Clustering feature(s)	Number of clusters found
Visser et al., 2007	Dutch university hospitals	Real-life	37	Progression	Clinical observations	Limb involvement	3
Gomeni and Fava, 2013	ProACT	Clinical trial	338	Progression	Unsupervised (non-linear Weibull model rajiestimation)	Clinical features	2
Balendra et al., 2014a	LiCALS, Mito Target	Clinical trial	725	Progression	Clinical observations	Clinical stages	5
Ko et al., 2014	ProAct	Clinical trial	1822	Progression	Clinical observations	ALSFRS decline rate	2
Elamin et al., 2015	Irish ALS registry, Italy (Piemonte Region)	Population	326	Outcome	Clinical observations	Score based on onset type, ALSFRS rate an executive disfunction	3
Marin et al., 2015	FRALim register	Population	322	Outcome	Unsupervised (RECPAM)	Clinical features	4

RECPAM, Recursive Partitioning and Amalgation.