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IGF-1 Fusion Proteins Triggered IGF-1 Receptor Signaling
MCF7 cells were serum starved for 16 h and treated with saline or 15 nM of different IGF-1 fusion proteins for 30 min and assessed for the phosphorylation of Akt (A) and Erk (B). All four IGF-1 fusion proteins were able to induce phosphorylation of Akt and Erk in MCF7 cells. (C) Potencies of IGF-1 fusion proteins (IGF1-c22, -c26, and -NT) were compared with IGF-1; all showed similar concentration-dependent responses.
