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. 2019 Feb 1;27(3):673–680. doi: 10.1016/j.ymthe.2019.01.017

Figure 3.

Figure 3

IGF-1 Fusion Proteins Triggered Metatarsal Bone Growth Ex Vivo

Fetal metatarsal bones were isolated from mouse embryos at embryonic day (E)18 and cultured for 3 days in the presence of IGF-1 itself or IGF-1 fusion proteins (IGF1-c22, -c26, and -NT). Compared with saline, IGF-1 or IGF-1 fusion proteins increased final bone length, suggesting that these fusion proteins are biologically active not only in cell culture but also in whole-bone culture. Line graph depicts mean ± SEM. *p < 0.05 versus saline (n = 6).