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. 2018 Jun 13;10(6):660. doi: 10.3390/polym10060660

Scheme 1.

Scheme 1

Representation of the synthesis of interpenetrating polymer network (IPN) nanoparticles (NPs). I) Reaction of the polysuccinimide (PSI) and graphite oxide (GO)-NH2 to the formation of a polyaspartic acid (PAsp) hydrogel, II) Polymerization of acrylic monomers onto and into the PAsp hydrogel, III) The formation of Ag, CuO, or ZnO nanoparticles inside the hydrogels, and IV) Loading of the drug inside the hydrogels.