Table 4.
Clinical Characteristics of Patients With ARVC/D Experiencing Inappropriate S‐ICD Therapy
| Clinical Variables | Overall Population (N=29) | No Inappropriate shock (n=23) | Inappropriate Shock (n=6) |
|---|---|---|---|
| Demographics | |||
| Male | 15 (52) | 13 (57) | 2 (33) |
| White | 28 (97) | 22 (96) | 6 (100) |
| Proband | 22 (76) | 16 (70) | 6 (100) |
| Mutation carrier | 16/27 (59) | 12/23 (57) | 4/6 (67) |
| Age at ICD implantation, y | 34±15 | 33±14 | 40±20 |
| Height, cm | 170 (165–175) | 173 (167–177) | 168 (164–175) |
| Weight, lb | 155 (135–176) | 150 (132–184) | 161 (147–175) |
| BMI, kg/m2 | 24±3 | 24±4 | 24±2 |
| Clinical characteristics at implant | |||
| Syncope | 10 (34) | 6 (26) | 4 (67) |
| Inducibility at EPS | 7/17 (41) | 3/11 (27) | 4/6 (67) |
| ≥1000 PVCs on Holter monitoring | 15/22 (68) | 11/17 (64) | 4/5 (80) |
| Inverted T‐waves in ≥3 precordial leads | 24/28 (86) | 18/22 (82) | 6/6 (100) |
| QRS duration, ms | 92 (82–100) | 90 (82–100) | 94 (79–100) |
| NSVT | 10 (34) | 11 (48) | 3 (50) |
| Major RV structural abnormality on CMR | 21/27 (72) | 16/21 (76) | 5/6 (83) |
| RVEF, % | 41 (35–49) | 43 (35–49) | 36 (34–48) |
| LVEF, % | 56 (45–63) | 57 (56–62) | 56 (45–63) |
| Device characteristics | |||
| First‐generation S‐ICD (Cameron Health; 1010) | 13/29 (45) | 10/13 (77) | 3/13 (23) |
| Second‐generation S‐ICD (Emblem A209, A219) | 16/29 (55) | 13/16 (81) | 3/16 (19) |
| Medications at implant | 24 (83) | ||
| ACEi/ARB | 24 (83) | 19 (83) | 5 (83) |
| β‐Blocker | 12 | 10 | 2 |
| Flecainide | 19 | 16 | 3 |
| Amiodarone | 2 | 1 | 1 |
| Sotalol | 1 | 1 | … |
Values are mean±SD, n (%), n/N (%), or median (interquartile range). ACEi indicates angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARVC/D, arrhythmogenic right ventricular cardiomyopathy/dysplasia; BMI, body mass index; CMR, cardiac magnetic resonance; EPS, electrophysiology study; ICD, implantable cardioverter‐defibrillator; LVEF, left ventricular ejection fraction; NSVT, nonsustained ventricular tachycardia; PVC, premature ventricular contraction; RV, right ventricular; RVEF, right ventricular ejection fraction; S‐ICD, subcutaneous implantable cardioverter‐defibrillator.