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. 2018 Nov 2;7(21):e009769. doi: 10.1161/JAHA.118.009769

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of short term estradiol replacement on myocardial collagen content and circulating biomarkers. Estradiol treated (E2) animals had significantly lower left ventricular (LV) free wall collagen (A) and serum monocyte chemoattractant protein 1 (MCP1) levels (B) compared to ovariectomized controls (CTL). Interleukin‐6 (IL6) (C) and vascular endothelial growth factor alpha (VEGFα) (D) were not significantly different (P=0.73 and 0.22 respectively). Data represent mean±SEM. *P<0.05 compared with controls to controls.