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. 2018 Nov 2;7(21):e009769. doi: 10.1161/JAHA.118.009769

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Scatterplots of expression levels of differentially expressed genes (DEGs) and echocardiographic and biomolecular phenotypes in estradiol and control (CTL) animals. Thrombospondin 1 (THBS1) negatively correlated with transmitral E velocity (A), Calmodulin 1 (CALM1) positively correlated with transmitral A velocity (B), matrix Gla protein (MGP) correlated positively with left ventricular collagen percentage (C), and TIMP metallopeptidase inhibitor 1 (TIMP1) correlated positively with monocyte chemoattractant protein 1 (MCP1) (D). Red symbols=control; blue symbols=estradiol treated.