Table 3.
Estradiol Regulated Genes in LV Myocardium
| Gene | Gene ID | Fold Difference | Raw P | FDR |
|---|---|---|---|---|
| Brain expressed, X‐linked 1 | BEX1 | 1.45 | 0.003 | 0.038 |
| von Willebrand factor | VWF | 1.37 | 0.007 | 0.045 |
| CD74 molecule, major histocompatibility complex, class II invariant chain | CD74 | 1.34 | 0.000 | 0.022 |
| Ryanodine receptor 2 | RYR2 | 1.34 | 0.004 | 0.041 |
| Nucleobindin 1 | NUCB1 | 1.28 | 0.012 | 0.047 |
| Calcium and integrin binding family member 2 | CIB2 | 1.30 | 0.002 | 0.036 |
| Nuclear fragile X mental retardation protein interacting protein 2 | NUFIP2 | 1.26 | 0.011 | 0.047 |
| Aldolase A, fructose‐bisphosphate | ALDOA | 1.26 | 0.004 | 0.044 |
| Chromosome 14 open reading frame 180 | C14orf180 | 1.27 | 0.002 | 0.036 |
| Tetraspanin 9 | TSPAN9 | 1.23 | 0.011 | 0.047 |
| Acyl‐CoA synthetase short‐chain family member 2 | ACSS2 | 1.24 | 0.011 | 0.047 |
| AF4/FMR2 family, member 3 | AFF3 | 1.24 | 0.001 | 0.022 |
| Ankyrin repeat and SOCS box‐containing 10 | ASB10 | 1.25 | 0.005 | 0.044 |
| Sirtuin 4 | SIRT4 | 1.25 | 0.007 | 0.045 |
| Poly(rC) binding protein 2 | PCBP2 | 1.22 | 0.006 | 0.045 |
| Enah/Vasp‐like | EVL | 1.22 | 0.002 | 0.036 |
| Protein phosphatase 2 regulatory subunit B | PPP2R3B | 1.21 | 0.007 | 0.045 |
| Beta‐1,3‐N‐acetylgalactosaminyltransferase 2 | B3GALNT2 | 1.21 | 0.001 | 0.022 |
| Pyruvate kinase, muscle | PKM2 | 1.21 | 0.004 | 0.041 |
| Smoothelin | SMTN | 1.21 | 0.005 | 0.044 |
| Calmodulin 1 | CALM1 | 1.21 | 0.011 | 0.047 |
| Ribonuclease P/MRP 40 kDa subunit | RPP40 | 1.22 | 0.009 | 0.047 |
| TIMP metallopeptidase inhibitor 1 | TIMP1 | −1.20 | 0.007 | 0.045 |
| Ribosomal protein S26 | RPS26 | −1.22 | 0.011 | 0.047 |
| Actin, γ2, smooth muscle, enteric | ACTG2 | −1.22 | 0.006 | 0.045 |
| Thrombospondin 1 | THBS1 | −1.23 | 0.011 | 0.047 |
| Leptin receptor overlapping transcript‐like 1 | LEPROTL1 | −1.25 | 0.004 | 0.043 |
| Chromosome 11 open reading frame 54 | C11orf54 | −1.25 | 0.003 | 0.038 |
| Carnitine palmitoyltransferase 2 | CPT2 | −1.26 | 0.001 | 0.022 |
| Chemokine (C‐X‐C motif) ligand 12 | CXCL12 | −1.28 | 0.006 | 0.045 |
| S100 calcium binding protein A4 | S100A4 | −1.28 | 0.001 | 0.027 |
| Thioredoxin interacting protein | TXNIP | −1.32 | 0.007 | 0.045 |
| RAB12, member RAS oncogene family | RAB12 | −1.35 | 0.005 | 0.044 |
| Peptidase inhibitor 16 | PI16 | −1.39 | 0.011 | 0.047 |
| Microfibrillar associated protein 5 | MFAP5 | −1.40 | 0.009 | 0.047 |
| Collagen, type I, α2 | COL1A2 | −1.51 | 0.007 | 0.045 |
| Matrix Gla protein | MGP | −1.65 | 0.005 | 0.044 |
| Pyruvate dehydrogenase kinase, isozyme 4 | PDK4 | −1.88 | 0.011 | 0.047 |
| Ribosomal protein S29 | RPS29 | −2.78 | 0.000 | 0.008 |
Genes with a Benjamini‐Hochberg FDR <0.05 and an estradiol induced fold change greater than 1.2 were considered significant. FDR indicates false discovery rate.