Table 4.
Adjusted Association of Continuous Measures of BMI and NP Z‐Score With Outcomes
| Primary End Point (N=199) | HF Hospitalization (N=161) | All‐Cause Mortality (N=111) | ||||
|---|---|---|---|---|---|---|
| HRa (95% CI) | P Value | HRa (95% CI) | P Value | HRa (95% CI) | P Value | |
| Per 1 SD higher log NP Z‐score | 1.28 (1.10–1.49) | 0.001 | 1.29 (1.10–1.52) | 0.002 | 1.43 (1.15–1.77) | 0.001 |
| Per 5‐unit higher BMI (below 25 kg/m2)a | 0.68 (0.31–1.48) | 0.33 | 0.87 (0.34–2.23) | 0.77 | 0.36 (0.16–0.79) | 0.01 |
| Per 5‐unit higher BMI (≥25 kg/m2) | 1.15 (1.03–1.29) | 0.01 | 1.25 (1.12–1.40) | 0.005 | 1.12 (0.95–1.33) | 0.20 |
Adjusted models includes age, sex, blood urea nitrogen, systolic blood pressure (linear spline with knot at 140 mm Hg), New York Heart Association class, sodium level, history of atrial fibrillation, history of diabetes mellitus, BMI (linear spline with knot at 25 kg/m2), and log NP Z‐score. BMI indicates body mass index; CI, confidence interval; HF, heart failure; HR, hazard ratio; NP, natriuretic peptide.
a
HR are reported per 5‐unit higher measure of BMI levels above and below the spline knot of 25 kg/m2.