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. 2018 Nov 2;7(21):e009777. doi: 10.1161/JAHA.118.009777

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Protein levels in the anterior and posterior leaflets between annuloplasty (URA), combination of annuloplasty and papillary muscle approximation (URA+PMA), and papillary muscle approximation (PMA) compared with the sham group of animals. A, Procollagen 1 C‐terminal propeptide. B, Procollagen 1 N‐terminal propeptide. C, Enzyme‐linked immunosorbent assay results for plasma procollagen type 1 N‐terminal propeptide. D, Prolyl 4‐hydroxylase 1. E, Heat shock protein 47; (F) Lysyl oxidase. HSP47 indicates heat shock protein 47; LO, lysyl oxidase; P4HA1, prolyl 4 hydroxylase; PICP, procollagen‐1 terminal C‐peptide; PINP, procollagen‐1 terminal N‐peptide.