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. 2018 Oct 23;7(21):e009624. doi: 10.1161/JAHA.118.009624

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Experimental design to examine the effects of sapropterin (tetrahydrobiopterin) on congenital heart defects induced by pregestational diabetes mellitus. A study flow chart illustrates timelines of saline or streptozotocin injection, breeding, sapropterin or insulin treatment, and assessments of fetal hearts in 5 groups of mice. BG indicates blood glucose; E, embryonic day; eNOS, endothelial NO synthase; IP, intraperitoneal injection; OFT, outflow tract; PO, oral administration; ROS, reactive oxygen species.