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. 2018 Oct 23;7(21):e009624. doi: 10.1161/JAHA.118.009624

Figure 1.

Figure 1

Experimental design to examine the effects of sapropterin (tetrahydrobiopterin) on congenital heart defects induced by pregestational diabetes mellitus. A study flow chart illustrates timelines of saline or streptozotocin injection, breeding, sapropterin or insulin treatment, and assessments of fetal hearts in 5 groups of mice. BG indicates blood glucose; E, embryonic day; eNOS, endothelial NO synthase; IP, intraperitoneal injection; OFT, outflow tract; PO, oral administration; ROS, reactive oxygen species.