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. 2018 Oct 23;7(21):e009624. doi: 10.1161/JAHA.118.009624

Figure 2.

Figure 2

Blood glucose levels of pregnant mice, percentage of successful plugs, litter size, fetal body weight, and biopterin levels. A, Nonfasting blood glucose levels from before mating (basal) to embryonic day (E) 18.5 during pregnancy in streptozotocin‐treated and control female mice with and without sapropterin (tetrahydrobiopterin) administration (n=4–8 mice per group). B, The percentage of successful pregnancies. The numbers in the parentheses indicate the number of successful pregnancies at the day of fetus harvest/total plugs. C, The offspring litter size measured at the day of fetus harvest (n=5–11 litters per group). D, Fetal body weight at E18.5 (n=5–8 fetuses per group). E through G, Levels of 7,8‐dihydrobiopterin in maternal plasma, and fetal 7,8‐dihydrobiopterin and tetrahydrobiopterin levels at E12.5 with or without tetrahydrobiopterin treatment in the diabetic dams (n=3–9 mice per group). Two‐way repeated‐measures ANOVA (A) or two‐way ANOVA (C and D), followed by Bonferroni post hoc test, was used. B was analyzed by Fisher's exact test. E through G were analyzed by unpaired Student t test. Data are means±SEM (A and C through G). *P<0.05, ***P<0.001 vs corresponding controls; †† P<0.001 vs untreated diabetes mellitus.