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. 2018 Oct 23;7(21):e009624. doi: 10.1161/JAHA.118.009624

Figure 4.

Figure 4

Effects of sapropterin (tetrahydrobiopterin) on fetal heart wall thickness of pregestational diabetes mellitus at embryonic day 18.5. A, Representative images of myocardial wall thickness in control and pregestational diabetes mellitus with and without tetrahydrobiopterin treatment. Arrows indicate compact myocardium boundary from which measurements were obtained. B and C, Quantification of left ventricular (LV) and right ventricular (RV) myocardial thickness, respectively. n=6 per group from 3 to 6 litters. Bar=200 μm. Data are means±SEM and analyzed using 2‐way ANOVA, followed by Bonferroni post hoc test (B and C). ***P<0.01 vs untreated control; † P<0.01 vs untreated diabetes mellitus.