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. 2018 Oct 23;7(21):e009243. doi: 10.1161/JAHA.118.009243

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Genes with significant eQTL at chromosome 10 and 17 PR interval associated loci. For each gene (A: Acbd4, B: Arhgap27, C: Cd300lg, D: Fam171a2 and E: Nhlrc1), from left to right: (1) Boxplots of PR interval duration for the SHR allele (genotype “0”) and BN allele (genotype “1”); (2) Boxplots of gene expression data for the SHR allele (genotype “0”) and BN allele (genotype “1”); (3) Scatterplot of gene expression vs PR interval duration, with the blue line a linear least‐squares fit and the underlying gray shading the estimated error. Gene expression data were corrected for the first principal component; expression levels are relative. BN indicates Brown Norway rat; eQTL, expression quantitative trait locus; SHR, spontaneously hypertensive rat.