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. 2018 Oct 23;7(21):e009243. doi: 10.1161/JAHA.118.009243

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Co‐expression network containing the significant eQTL genes Acbd4, Fam171a2, and Cd300lg. Overview of the co‐expression network of 31 genes, containing 3 candidate genes identified through eQTL analysis. A, Heatmap showing the Spearman correlation between gene expression patterns of each gene pair. Blue signifies negative correlation, while orange signifies positive correlation. The 3 candidate genes, Fam171a2, Cd300lg, and Acbd4, are highlighted by gray arrows. B, Density distribution plot of the Spearman correlation values for each gene in the network with PR interval in channel 1 (solid line) and channel 2 (dashed line). This figure summarizes the correlation of the network with PR interval on gene level. C, Scatterplot of the network eigengene values vs PR interval. Dotted lines represent the linear least‐squares fits for channel 1 (light blue) and channel 2 (gray). Spearman Rho correlation values are given in the legend for each channel. This figure summarizes the correlation of the network with PR on network level. eQTL indicates expression quantitative trait locus.