Table 2.
Myocardial Function by Right Heart Catheterization and by Echocardiography in Cardiac Amyloidosis Patients
| Resting Conditions | Peak Exercise | P Value | |
|---|---|---|---|
| Hemodynamics | |||
| MAP, mm Hg | 90±10 | 104±27 | <0.05 |
| HR, beats/min | 76±17 | 123±27 | <0.0001 |
| CI, L/min per m2 | 2.3±0.6 | 4.4±2.1 | <0.0001 |
| VO2, mL/min per kg | 301±89 | 1156±496 | <0.0001 |
| mRAP, mm Hg | 6.8±4.4 | 16±9 | <0.0001 |
| mPAP, mm Hg | 25±9 | 46±11 | <0.0001 |
| mPCWP, mm Hg | 15±7 | 31±8 | <0.0001 |
| PAC, mL/mm Hg | 3.6±2.3 | 2.6±1.7 | <0.01 |
| Echocardiography | |||
| IVS, mm | 15.8±5.0 | ||
| PWT, mm | 13.8±3.6 | ||
| 3D LV mass, g/m2 | 129±33 | ||
| 2D LVEF Simpson Biplane, % | 54±13 | 57±14 | 0.10 |
| LVGLS, % | 12±4 | 13±6 | 0.12 |
| Strain apical segments, % | 17±5 | 21±8 | <0.01 |
| Strain basal segments, % | 7.5±5.3 | 7.7±6.4 | 0.74 |
| A‐B strain diff, % | 9.7±4.2 | 12.9±4.7 | <0.01 |
| MWE, mm Hg L/min per g | 1.9±1.0 | 4.4±3.6 | <0.001 |
| E/A (ratio) | 2.2±1.4 | 2.4±1.2 | 0.97 |
| E/e′ (ratio) | 22±13 | 22±14 | 0.76 |
| LA volume, mL/m2 | 42±19 | ||
| RA volume, mL/m2 | 34±22 | ||
| TAPSE, cm | 1.8±0.7 | ||
| RVS′, cm/s | 8.9±2.4 | ||
2D indicates two‐dimensional; 3D, three‐dimensional; A‐B, apical to basal; CI, cardiac index; HR, heart rate; IVS, interventricular septal thickness; LA, left atrium; LVEF, left ventricular ejection fraction; LVGLS, left ventricular global longitudinal strain; MAP, mean arterial blood pressure; mPAP, mean pulmonary artery pressure; mPCWP, mean pulmonary capillary wedge pressure; mRAP, mean right atrial pressure; MWE, myocardial work efficiency; PAC, pulmonary arterial compliance; PWT, posterior wall thickness; RA, right atrium; RVS’, peak systolic velocity of tricuspid annulus; TAPSE, tricuspid annular plane systolic excursion; VO2, external oxygen consumption.