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. 2019 Mar 7;12:49. doi: 10.1186/s12920-019-0494-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Gut microbiota variability before HSCT, in relation to aGvHD development. a PCoA based on Bray-Curtis distances of genus-level relative abundance profiles of samples collected before HSCT from patients who did not develop aGvHD (green), who developed aGvHD (I-II grade) only involving the skin (gold), and who developed gastrointestinal aGvHD (II-IV grade) (dark red). Samples are identified by filled circles. First and second principal components (MDS1 and MDS2) are plotted, accounting for 22.1 and 13.3% of variance in the dataset, respectively. Box and whiskers distribution of the relative abundance (%) of OTUs assigned to the genera Fusobacterium (b) and Blautia (c) in samples collected before HSCT from subjects who did not develop aGvHD (green), who developed aGvHD (I-II grade) only involving the skin (gold), and who developed gastrointestinal aGvHD (II-IV grade) (dark red)