. 2019 Mar 7;19:71. doi: 10.1186/s12887-019-1448-0

Table 4.

Comparison of the frequency of VDR gene Apal polymorphism genotypes among different age-of-onset sub-groups of Kuwaiti TIDM patients

ApaI Genotype/Age of onset sub-groups	Frequency (%)	OR (95% CI)*	P-value**
GG-genotype
< 4 years vs	7/28 (25)	1.53 (0.42–5.57)	0.74
4–6 years	5/28 (18)	1.53 (0.42–5.57)	0.74
< 4 years vs	7/28 (25)	0.25 (0.08–0.77)	0.02
> 6 years	16/28 (57)	0.25 (0.08–0.77)	0.02
4–6 years vs	5/28 (18)	0.16 (0.04–0.55)	0.005
> 6 years	16/28 (57)	0.16 (0.04–0.55)	0.005
GT-genotype
< 4 years vs	7/31 (22.6)	1.22 (0.36–4.14)	1.0
4–6 years	6/31 (19.4)	1.22 (0.36–4.14)	1.0
< 4 years vs	7/31 (22.6)	0.21 (0.07–0.64)	< 0.01
> 6 years	18/31 (58.0)	0.21 (0.07–0.64)	< 0.01
4–6 years vs	6/31 (19.4)	0.17 (0.06–0.54)	< 0.01
> 6 years	18/31 (58.0)	0.17 (0.06–0.54)	< 0.01
TT-genotype
< 4 years vs	34/188 (18.0)	0.58 (0.35–0.94)	0.04
4–6 years	52/188 (27.7)	0.58 (0.35–0.94)	0.04
< 4 years vs	34/188 (18.0)	0.19 (0.12–0.30)	< 0.0001
> 6 years	102/188 (54.3)	0.19 (0.12–0.30)	< 0.0001
4–6 years vs	52/188 (27.7)	0.32 (0.21–0.50)	< 0.0001
> 6 years	102/188 (54.3)	0.32 (0.21–0.50)	< 0.0001

*OR (95% CI), odds ratio 95% confidence interval; **P-values were considered significant when < 0.05. The age-of-onset information was not available in 5 T1DM patients (data available from 248 T1DM patients). In one T1DM patient the ApaI genotype could not be determined, therefore data reported from 247 cases