Table 7.
Comparison of VDR gene haplotype frequencies in Kuwaiti T1DM patients and controls
| Haplotypea | Patients (%) N = 202 | Controls (%) N = 154 | Odds ratio (95% CI)* | P-value** |
|---|---|---|---|---|
| f/C/G/b | 6 (3) | 0 | 10.22 (0.571–182.97) | 0.038 |
| f/C/G/B | 5 (2.5) | 1 (0.6) | 3.88 (0.448–33.603) | 0.24 |
| F/C/G/B | 1 (0.5) | 2 (1.3) | 0.38 (0.034–4.211) | 0.58 |
| f/T/G/b | 5 (2.5) | 6 (3.9) | 0.63 (0.187–2.091) | 0.54 |
| F/T/G/b | 0 | 2 (1.3) | 0.15 (0.007–3.163) | 0.18 |
| f/T/GB | 6 (3) | 16 (10.4) | 0.26 (0.100–0.69) | 0.006 |
| F/T/G/B | 2 (1) | 7 (4.5) | 0.21 (0.043–1.03) | 0.04 |
| f/C/T/b | 23 (11.4) | 4 (2.6) | 4.81 (1.630–14.245) | 0.002 b |
| F/C/T/b | 8 (4) | 10 (6.5) | 0.59 (0.228–1.543) | 0.33 |
| f/C/T/B | 45 (22.3) | 6 (3.9) | 7.07 (2.929–17.065) | < 0.0001 b |
| F/C/T/B | 14 (6.9) | 14 (9.1) | 0.75 (0.345–1.613) | 0.58 |
| f/T/T/b | 20 (9.9) | 14 (9.1) | 1.10 (0.536–2.253) | 0.93 |
| F/T/T/b | 6 (3) | 20 (13) | 0.21 (0.080–0.524) | 0.0004 |
| f/T/T/B | 48 (23.8) | 25 (16.2) | 1.61 (0.939–2.752) | 0.11 |
| F/T/T/B | 13 (6.4) | 27 (17.5) | 0.32 (0.161–0.651) | 0.002 |
aThe VDR gene haplotypes were documented as described earlier [18] and the haplotypes were described in the order FokI/TaqI/ApaI/BsmI; b The haplotypes containing majority of variant alleles and with highest OR are shown in bold. *OR (95% CI), Odds ratio at 95% Confidence interval; * P-values were considered significant when < 0.05