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. 2018 Dec 21;30(4):400–409. doi: 10.1007/s11825-018-0216-0

Fig. 1.

Fig. 1

The complement system. The complement system can be activated by three pathways: the classical, lectin or alternative pathway. All three activation pathways merge in the activation of complement C3. The terminal complement pathway is activated via the activation of complement C5, resulting in the formation of the membrane attack complex. FH factor H, MCP/CD46 membrane cofactor protein, DAF/CD55 decay accelerating factor, MAC/C5b‑9 membrane attack complex