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. 2018 Dec 21;30(4):400–409. doi: 10.1007/s11825-018-0216-0

Fig. 3.

Fig. 3

FH::FHR hybrid genes related to aHUS. FH::FHR1, FHR1::FH, and FH::FHR3 hybrid genes are known to be related to aHUS and cause loss of complement regulation on the endothelial cell surface. Pink SCRs are SCRs from FH, whereas dark purple SCRs are related to FHR1 or FHR3.

FH factor H, FHR factor H-related protein, SCR short consensus repeat