Fig. 5.

Historical timeline of the main highlights of TMA and aHUS. Timeline of major TMA- and aHUS-related findings starting in 1924 with the first description of TMA by Moschcowitz [1–3]. Orange dots are related to the main events in the story of TMA, whereas green dots are related to mutations found in aHUS.

TMA thrombotic microangiopathy, HUS hemolytic uremic syndrome, aHUS atypical hemolytic uremic syndrome, TTP thrombotic thrombocytopenic purpura, FH factor H, MCP/CD46 membrane cofactor protein, FI factor I, FHRs factor H-related proteins, FB factor B, THBD/CD141 thrombomodulin, DGKE diacylglycerol kinase epsilon, INF2 inverted formin-2