Table 2.
Predictors of Exaggerated Blood Pressure Response in Univariate and Multivariate Logistic Regression Analyses in Moderate or Severe Aortic Stenosis
| Univariate | Multivariate | |||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Age, y | 1.02 (0.99–1.05) | 0.065 | 1.05 (1.00–1.10) | 0.046 |
| Male sex | 1.25 (0.67–2.28) | 0.461 | ||
| Weight, kg | 1.01 (0.99–1.03) | 0.415 | ||
| Body mass index, kg/m2 | 0.99 (0.96–1.03) | 0.838 | ||
| Clinic SBP (per 1SD [7.5 mm Hg] increase) | 2.93 (2.03–4.21) | <0.001 | ||
| Clinic DBP, mm Hg | 1.00 (0.98–1.03) | 0.703 | ||
| Pre‐test SBP (per 1SD [7.4 mm Hg] increase) | 2.39 (1.71–3.34) | <0.001 | ||
| Pre‐test DBP (per 1SD [7.7 mm Hg] increase) | 1.20 (0.90–1.58) | 0.216 | ||
| Hypertension | 2.48 (1.20–5.14) | 0.014 | 1.57 (0.50–4.88) | 0.437 |
| Antihypertensive treatment | 1.64 (0.79–3.41) | 0.189 | ||
| Diabetes mellitus | 0.83 (0.34–2.01) | 0.65 | ||
| Hypercholesterolemia | 2.43 (0.86–6.87) | 0.093 | ||
| Aortic annulus diameter, mm | 0.22 (0.05–0.94) | 0.040 | 1.14 (0.10–13.40) | 0.917 |
| LV ejection fraction (%) | 1.05 (1.00–1.10) | 0.045 | 1.05 (0.97–1.14) | 0.206 |
| Left atrium diameter, cm | 1.04 (0.99–1.09) | 0.088 | 0.96 (0.89–1.04) | 0.303 |
| Interventricular septal thickness, cm | 2.80 (0.94–8.33) | 0.064 | ||
| Posterior wall thickness, cm | 5.80 (1.50–22.42) | 0.011 | ||
| LV mass (per 1 SD [2.8 g] increase) | 1.43 (1.07–1.91) | 0.015 | 2.04 (1.23–3.38) | 0.012 |
| High LV mass, g/m2.7 | 2.19 (1.04–4.64) | 0.040 | ||
| LV hypertrophy | 2.19 (1.04–4.64) | 0.039 | ||
| Abnormal LV geometry | 10.23 (1.35–77.27) | 0.024 | ||
| Effective orifice area, cm2 | 1.65 (0.46–5.87) | 0.441 | ||
| Doppler stroke volume, mL/m2 | 1.00 (0.99–1.02) | 0.586 | ||
| PP/SVi, mm Hg/mL per m2 | 2.58 (1.63–4.88) | 0.004 | 2.47 (1.02–6.00) | 0.037 |
| Low SAD (SVi/PP ≤0.6 mL/m2 per mm Hg) | 2.48 (1.15–5.33) | 0.020 | ||
CI indicates confidence interval; DBP, diastolic blood pressure; HbA1c, hemoglobin A1c; LV, left ventricular; OR, odds ratio; PWV, pulse wave velocity; SAD; systemic arterial distensibility; SBP, systolic blood pressure.