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. 2019 Jun;14(6):1013–1024. doi: 10.4103/1673-5374.250620

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Schematic of areas taken for analysis and experimental design.

(A) Sham group and (B) SAH group. (C) Experiment 1 was designed to determine involvement of the Wnt/Frizzled signaling pathway in EBI under SAH condition. (D) Experiment 2 was designed to determine involvement of neuroprotection through the Wnt/Frizzled signaling pathway via suppression of the inflammatory response. SAH: Subarachnoid hemorrhage; EBI: early brain injury; h: hours; wk: week; IL: interleukin; TNF: tumor necrosis factor; SD: Sprague-Dawley; ELISA: enzyme-linked immunosorbent assay; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling.