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. 2019 Mar 7;114:e180517. doi: 10.1590/0074-02760180517

TABLE III. Results of seropositivity seroconversion and geometric mean titer (GMT) (per protocol analyses).

Component After MMR After MMRV
MMR-Bio (N = 322) MMR-GSK (N = 113) MMR-Bio (N = 322) MMR-GSK (N = 113)
Measles
Seropositivity (%) (CI 95%) 97,2 (95,4; 99,0) 98,2 (95,8; 100,0) 100,0 - 100,0 -
Difference of seropositivity (%) (CI 95%) -1,03 (-4,0; 2) 0,0
GMT (CI 95%) 3069,0 (2791,9; 3373,6) 3457,3 (2962,7; 4034,5) 3783,8 (3510,1; 4078,8) 3885,7 (3420,2; 4414,6)
GMT ratio of MMR-Bio/MMR-GSK (CI 95%) 0,89 (0,7; 1,1) 1,0 (0,8; 1,1)
Seroconversion (%) (CI 95%) 95,0 (92,6; 97,4) 95,6 (91,7; 99,4) 97,8 (96,2; 99,4) 97,3 (94,3; 100,0)
Difference of seroconversion (%) (CI 95%) -0,5 (-5,0; 3,9) 0,5 (-2,9; 3,8)
Mumps
Seropositivity (%) (CI 95%) 86,0 (82,2; 89,8) 85,8 (79,3; 92,4) 99,4 (98,5; 100,0) 99,1 (97,4; 100,0)
Difference of seropositivity (%) (CI 95%) 0,2 (-7,3; 7,6) 0,3 (-1,7; 2,2)
GMT (CI 95%) 1057,1 (950,2; 1176,0) 1054,9 (881,1; 1263,0) 3495,9 (3250,5; 3759,8) 4208,2 (3718,1; 4762,8)
GMT ratio of MMR-Bio/MMR-GSK (CI 95%) 1,0 (0,8; 1,2) 0,8 (0,7; 1,0)
Seroconversion (%) (CI 95%) 84,5 (80,5; 88,4) 83,2 (76,2; 90,2) 97,8 (96,2; 99,4) 96,5 (93; 99,9)
Difference of seroconversion (%) (CI 95%) 1,3 (-6,7; 9,2) 1,4 (-2,4; 5,1)
Rubella
Seropositivity (%) (CI 95%) 97,5 (95,8; 99,2) 99,1 (97,4; 100,0) 100,0 - 100,0 -
Difference of seropositivity (%) (CI 95%) -1,60 (-4,02; 0,82) 0,0
GMT (CI 95%) 56,0 (51,5; 60,8) 61,4 (54,4; 69,3) 70,7 (66,3; 75,4) 77,8 (69,9; 86,5)
GMT ratio of MMR-Bio/MMR-GSK (CI 95%) 0,91 (0,8; 1,1) 0,9 (0,8; 1,0)
Seroconversion (%) (CI 95%) 96,3 (94,2; 98,4) 96,5 (93,0; 99,9) 98,8 (97,5; 100,0) 97,3 (94,3; 100,0)
Difference of seroconversion (%) (CI 95%) -0,2 (-4,2; 3,8) 1,4 (-1,8; 4,6)
Varicella
Seropositivity (%) (CI 95%) - - - - 71,4 (66,5; 76,4) 70,8 (62,3; 79,3)
GMT (CI 95%) - - - - 132,1 (119,6; 145,9) 143,8 (119,2; 173,4)
GMT ratio of MMR-Bio/MMR-GSK (CI 95%) 0,9 (0,8; 1,1)
Seroconversion (%) (CI 95%) - - - - 68,3 (63,2; 73,4) 64,6 (55,6; 73,6)

CI: confidence interval; GMT: geometric mean titre; GSK: GlaxoSmithKline; MMR: measles, mumps, and rubella; MMRV: measles, mumps, and rubella vaccine.