Table 1.

Gene-Based association p-values of linkage-based selected functional coding and non-coding variants in MTRNR2L4, RBFOX1, and SLX4

		SBP			DBP			PP
Gene a	NVARb	BurdenVT c	BurdenCMC c	SKAT c	BurdenVT	BurdenCMC	SKAT	BurdenVT	BurdenCMC	SKAT
CFS-EA Coding, N = 395
RBFOX1	3	0.012	0.456	0.024	0.11	0.342	0.064	0.001	0.042	0.014
SLX4	10	0.12	0.851	0.056	0.16	0.569	0.035	0.52	0.687	0.572
CFS-EA Non-coding, N = 395
MTRNR2L4	2	0.05	0.048	0.101	0.012	0.01	0.027	0.55	0.576	0.8
RBFOX1	86	0.95	0.71	0.036	0.29	0.213	0.257	0.59	0.566	0.114
SLX4	3	0.22	0.11	0.107	0.022	0.009	0.007	0.99	0.931	1
CFS-EA Coding + Non-coding, N = 395
MTRNR2L4	2	0.045	0.048	0.101	0.013	0.010	0.027	0.550	0.576	0.800
RBFOX1	89	0.890	0.323	0.036	0.340	0.571	0.266	0.230	0.044	0.087
SLX4	13	0.034	0.851	0.047	0.006	0.569	0.003	0.690	0.687	0.861
EA Meta-Analysis Coding, N = 18,025
RBFOX1	3	0.051	0.021	0.478	0.042	0.025	0.308	0.554	0.320	0.546
SLX4	10	0.086	0.069	0.071	0.599	0.901	0.301	0.004	0.001	0.021
EA Meta-Analysis Non-coding, N = 18,025
MTRNR2L4	2	0.002	0.685	0.085	0.013	0.853	0.446	0.037	0.531	0.075
RBFOX1	86	0.384	0.926	0.032	0.712	0.98	0.091	0.624	0.94	0.493
SLX4	3	0.379	0.493	0.649	0.995	0.908	0.986	0.046	0.091	0.151
EA Meta-Analysis Coding + Noncoding, N = 18,025
MTRNR2L4	2	0.002	0.685	0.085	0.013	0.853	0.446	0.035	0.531	0.075
RBFOX1	89	0.222	0.007	0.009	0.078	0.037	0.013	0.630	0.126	0.598
SLX4	13	0.071	0.093	0.086	0.917	0.554	0.621	2.19E-04	0.006	0.009

^aGene: only genes with at least 1 gene-based test p < 0.05 in stage I discovery analysis were moved forward for stage I replication

^bNVAR: number of passed variants; only include linkage-based selected functional coding variants and rare non-coding variants with MAF < 1%, CADD > 10

^cBurdenVT, BurdenCMC, and SKAT are gene-based tests described in the Methods section.