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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Hum Genet. 2019 Jan 22;138(2):199–210. doi: 10.1007/s00439-019-01975-0

Table 3.

Gene-Based association p-values for GeneHancer elements

SBP DBP PP
Enhancer Target NVARa BurdenVT BurdenCMC SKAT BurdenVT BurdenCMC SKAT BurdenVT BurdenCMC SKAT
All European-American Cohorts, N = 18,420
MTRNR2L4 20 0.028 0.015 0.144 0.216 0.007 0.356 0.014 0.032 0.113
RBFOX1 3 0.005 0.032 0.148 0.025 0.031 0.144 0.027 0.120 0.137
SLX4 26 0.046 0.047 0.026 0.199 0.365 0.046 0.081 0.005 0.055
a

NVAR: number of passed variants; only include linkage-based selected functional coding variants and available rare non-coding variants with MAF < 5% and CADD > 10