Figure 6.

Immunohistochemical staining in white matter lesions with anti‐TREX1. A. Staining for Iba1 and TREX1 in white matter lesions from cases with RVCL (left) or ischemic stroke (right). Representative images from chronic lesions are shown (400x magnification) with each successive image taken from two high‐powered fields away. Staining for Iba1 and TREX1 is developed with DAB (brown). Nuclei are counterstained with hematoxylin (blue). Scale bar represents 100 μm. B. Panoramic view of the morphological changes in TREX1⁺ cells around a chronic lesion in ischemic stroke (right side) and their tracking in the adjacent white matter (WM) with relative absence of TREX1⁺ cells in the gray matter (GM). Similar findings are noted in RVCL lesions. Scale bar represents 1 mm.