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. Author manuscript; available in PMC: 2019 Mar 7.
Published in final edited form as: Cell Rep. 2016 Feb 18;14(8):1892–1900. doi: 10.1016/j.celrep.2016.02.001

Figure 1. On-Off and Sustained-Transient Organization of the IPL.

Figure 1.

(A) The IPL is divided into On and Off (gray shading) sublayers, which support On BC-GC wiring and Off BC-GC wiring specificity.

(B) Observations of BC visual responses (Baden et al., 2013; Borghuis et al., 2013) suggest a tentative further division of the IPL into On-sustained, On-transient, Off-transient, and On-sustained sublayers. The two sustained-transient divisions are located at the depths of On and Off SACs.

(C) Analogous wiring specificity for On and Off BC-SAC circuits. Sustained BCs prefer the proximal zone of SACs and transient BCs prefer the intermediate or distal zones of SACs.

(D) When viewed perpendicular to the light axis, On (blue) and Off (red) SACs appear mirror symmetric across the plane separating the On and Off sublayers of the IPL.

(E) The same SACs appear similar when viewed along the light axis. A BC axon (green) is much smaller. The black circles and gray dots respectively indicate reconstructed On and Off SAC cell body locations. The On BCs were reconstructed in a patch (dashed rectangle). The scale bar represents 50 μm.