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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Gene Ther. 2018 Aug 28;25(7):473–484. doi: 10.1038/s41434-018-0038-3

Scheme 1. Structure of ssmRNA, dsmRNA1, ssmRNA(80A), dsmRNA2, and dsmRNA(80A).

Scheme 1.

The schematic drawing of forward and reverse mRNA used to prepare dsmRNA is illustrated. Reverse strand hybridization of 3’ and 5’ UTRs distinguishes dsmRNA1 from dsmRNA2. Reverse strand hybridization with the poly(A) tail is included in dsmRNA(80A).