Table 3.
Incidence rate and hazard ratios of type-specific incident hand and genital HPV DNA positivity stratified by HPV positivity at other sites at the previous visit, pooled over all HPV types.
| Exposure site positive |
Exposure site negative |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome | Exposure site | Number at riska | Events (n)a | Incidence rate (/100 years) | Number at riska | Events (n)a | Incidence rate (/100 years) | Univariate HR (95% CI) | Adjusted for all sitesb HR (95% CI) |
| Women | |||||||||
| Incident hand | Genital (own) | 223 | 45 | 50·6 | 7218 | 33 | 1·0 | 51·0 (31·4–82·7) | 17·9 (8–8-36–5) |
| positivity | Genital (partner) | 284 | 39 | 32·5 | 6633 | 30 | 1·0 | 33·8 (20·2–56·5) | 5·9 (2–8-12–4) |
| Hand (partner) | 80 | 16 | 48·3 | 6909 | 54 | 1·7 | 26·7 (14·3-49·8) | 1·4 (0·7-2·8) | |
| Incident genital | Hand (own) | 34 | 5 | 29·9 | 7140 | 101 | 3·1 | 9·8 (3·8-25·4) | 2·7 (0·8-8·5) |
| positivity | Genital (partner) | 164 | 28 | 38·2 | 6435 | 62 | 2·1 | 19·2 (12·0-30·8) | 19·3 (11·8-31·8) |
| Hand (partner) | 41 | 3 | 15·5 | 6630 | 87 | 2·9 | 5·0 (1·5-16·4) | 0·5 (0·1-1·8) | |
| Men | |||||||||
| Incident hand | Genital (own) | 221 | 34 | 45·8 | 6496 | 42 | 1·6 | 27·4 (16·7-45·0) | 7·2 (3·4-15·5) |
| positivity | Genital (partner) | 170 | 28 | 50·2 | 6090 | 37 | 1·5 | 31·7 (18·5-54·2) | 9·5 (4·3-21·1) |
| Hand (partner) | 57 | 8 | 39·2 | 6238 | 57 | 2·3 | 14·3 (6·4-32·3) | 1·0 (0·4-2·7) | |
| Incident genital | Hand (own) | 25 | 3 | 29·8 | 6496 | 89 | 3·4 | 8·7 (2·6-29·5) | 0·5 (0·1-3·1) |
| positivity | Genital (partner) | 90 | 22 | 75·5 | 5921 | 58 | 2·4 | 33·3 (19·4-57·1) | 28·4 (15·4-52·1) |
| Hand (partner) | 37 | 8 | 59·5 | 6005 | 72 | 3·0 | 17·4 (7·9-38·5) | 2·3 (0·9-6·2) | |
CI=Confidence interval; HPV=human papillomavirus; HR=Hazard ratio; n=number of events.
The number at risk is 36 HPV types * the number of instances where both the exposure and the outcome baseline site samples were valid and taken on the same day, and which have valid follow-up data for the outcome site. Total numbers at risk and number of events vary between rows because some individuals contribute to some analyses but not others if one of their samples is invalid.
Incident hand positivity: mutually adjusted for genital (own), genital (partner), and hand (partner) exposure site positivity; Incident genital positivity: mutually adjusted for hand (own), genital (partner), and hand (partner) exposure site positivity.