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Pharmacologic inhibition of metalloprotease activity leads to the intracellular accumulation of Aβ aggregates. A) Treatment of SH-SY5Y-APP cells with PA (100 μM, 48 h) produced a significant increase in extracellular Aβ, compared with nontreated cells (control, C). B, C) Intracellular levels of Aβ40 (B) and oAβ (C) were also significantly elevated in PA-treated cells (n = 3 per group). ***P < 0.001, ****P < 0.0001.
