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. 2018 Nov 27;33(3):3758–3771. doi: 10.1096/fj.201801319R

Figure 8.

Figure 8

Aβ species including oAβ are present in both extracellular and intracellular fractions from young TgCRND8 mouse brains. Levels of human Aβ40 (A, B), human/rodent Aβ42 (C, D), and oAβ (E, F) were measured in the Tris-soluble, extracellular enriched fraction and the RIPA-extracted intracellular vesicle fraction from 2-mo-old (preamyloid deposition) TgCRND8 mouse brains (n = 10). Identically prepared extracts from wild-type (wt) littermates (n = 5) were included as controls to validate Aβ measurements in transgenic mice. For every assay, the signal in TgCRND8 transgenic mice was significantly higher than in wild-type mice. **P < 0.01, ***P < 0.001, ****P < 0.0001.